Truncated beta‐helices maintain template‐assisted hemolysis

Vitamin-Induced Hemolysis

Case Summary A 47 year-old African American man presented to the hospital with three a day history of fever, shortness of breath, nausea, emesis, dark urine, and progressive confusion. The symptoms began one day following an infusion of a “vitamin complex” at his physician’s office. The patient’s medical history was significant for retroperitoneal fibrosis with multiple urological procedures, f...

Oxidative Hemolysis and Precipitation

The propensity of certain chemicals and drugs to induce hemolytic anemias has been a subject of much interest for almost a century (1-4). The majority of substances so active are aromatic compounds containing amino-, nitro-, or hydroxy groups, although a number of inorganic compounds (e.g., hydroxylamines, nitrates, nitrites and chlorates) are also active (1-4). Such compounds usually cause red...

Bacterial hemagglutination and hemolysis.

Cobra Venom-induced Hemolysis

Interest in the alternate or C3 shunt complement pathway has recently been generated by a number of reports (1-5). Its presence in invertebrates points to a primitive phylogenetic appearance (6). The C3 shunt can be triggered by high molecular weight polysaccharides in a manner reminiscent of the properdin system (7). Once activated by cobra venom, erythrocytes and other cells can be lysed in t...

Non-immune Hemolysis: Diagnostic Considerations.

Non-immune hemolytic anemia (NIHA) is characterized by positive routine hemolytic tests but negative anti-human immunoglobulin (Coombs) test. Hereditary non-immune hemolysis includes disorders of erythrocytic enzymes, membrane, hemoglobin (qualitative and quantitative disorders), as well as the rare hereditary forms of thrombotic microangiopathies. Acquired NIHA includes paroxysmal nocturnal he...